Risk of warfarin association with bleeding with antibiotics

Baillergeon J. et al.  Am J Med 2012; 125:183-9.

 

Antibiotic (class)          odds ratio of bleeding (univariate/multivariate)

 

Azole antifungals             6.49/4.57

macrolides                      2.09/1.86

quinolones                      2.20/1.69

cotrimoxazole                 3.06/2.70

penicillins                       1.89/1.92

cephalosporins                2.85/2.45

 

Use of other meds

 

SSRI                               1.45/1.34

SNRI                               1.34/1.17

corticosteroid                   2.58/2.30

antiplatelet                       1.57/1.43

CYP2CP                          1.11/1.07